Disorder (7/20)

The disorder occurs when the genes responsible for the proteins found in the outermost layer of the skin mutate. Abnormalities, such as the impaired regulation of body temperature, water retention, and resistance to infections, can be observed. 

These mutations are the cause of 90% of lamellar ichthyosis cases. The other 10% is not as widely known, as some result from a deviation in various genes, while others are unknown.